Plasmodium sporozoites develop within oocysts in the mosquito midgut wall and then migrate to the salivary glands. Plasmodium yoelii 17XNL is a nonlethal strain in the blood of a wild thicket rat ( Thamnomys rutilans) endemic to La Moboke, near Bangui in the Central African Republic, originally isolated in 1965 (Landau and Chabaud, 1965). Plasmodium yoelii 17XNL was recovered from frozen pRBC stock by passage in mice after intraperitoneal (i.p.) inoculation, and the challenge infections were induced with i.p. Plasmodium yoelii yoelii 17XNL constitutively expressing GFP throughout the life cycle Takeshi Ono , 1, 2 Takushi Tadakuma , 2 and Ana Rodriguez 1, * 1 New York University School of Medicine, Department of Medical Parasitology, 341 E 25 th street, New York, NY 10010, USA. Because virulence in this parasite correlates with the ability to invade different types of erythrocytes, we evaluated the potential role of the parasite erythrocyte binding ligand, Py EBL. Transmission of the sexual stages of the parasite to mosquitoes requires the proper regulation of specific mRNAs. inoculations of 1 × 10 7 fresh pRBCs from donor mice. caused by other Plasmodium species remains to be determined. Survival and parasitemia were measured to After transmission, they embark on a complex journey to the mammalian liver, where they infect hepatocytes. yoelii 17XNL parasite to examine the differentiation of Plasmodium-specific CD4 + T cells and B cells in mice with and without cGAS during blood-stage infection. To examine antigen-specific CD4 + T cells responding to infection, P . Plasmodium yoelii 17XL is a lethal strain cloned from P. yoelii 17XNL … The major virulence determinant of the rodent malaria parasite, Plasmodium yoelii , has remained unresolved since the discovery of the lethal line in the 1970s.

In this report, we have investigated the role of CD47 on the growth and survival of nonlethal Plasmodium yoelii 17XNL … In the present study, we have examined the roles of IL-3 in host defense against blood-stage malaria by using IL-3-deficient or “knockout” (KO) mice infected with either nonlethal P. yoelii 17XNL or lethal P. yoelii YM parasites. CD47 is a marker of self on most cells, including RBC, which, in conjunction with signal regulatory protein alpha (expressed on macrophages), prevents the clearance of cells by the immune system.

Proteins on the sporozoite surface likely mediate multiple steps of this journey, yet only a few sporozoite surface proteins have been described. Parasitemia and survival rates were monitored daily thereafter. Therefore, the anti-leukaemia effect of P. yoelii 17XNL infection is not associated with hyperthermia. However, the P. yoelii 17XNL strain does not induce fever in rodent malaria , and we did not observe fever in the animals in our study (data not shown). Author summary Malaria is a disease caused by Plasmodium parasites, which are transmitted during an infectious blood meal by anopheline mosquitoes.

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